The 10 top performers
| # | Fund | 30 days | Net assets | Cost | Yield | 1 mo | YTD | 1 yr | 3 yr | 5 yr |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | FBT First Trust NYSE Arca Biotechnology Index Fund | $2.81B | 0.55% | 0% | +0.3% | +32.5% | +43.6% | +27.7% | +11.4% | |
| 2 | BBH VanEck Biotech ETF | $395.6M | 0.35% | 0.38% | +1.8% | +32.0% | +41.0% | +20.9% | +5.4% | |
| 3 | BBP Virtus LifeSci Biotech Products ETF | $98.5M | 0.34% | 0% | +0.2% | +31.2% | +40.3% | +32.3% | +15.6% | |
| 4 | XBI SPDR S&P Biotech ETF | $10.73B | 0.35% | 0.36% | -0.1% | +27.1% | +39.3% | +34.4% | +5.0% | |
| 5 | PBE Invesco Biotechnology & Genome ETF | $281.9M | 0.59% | 1.32% | +3.6% | +24.0% | +38.6% | +25.2% | +6.8% | |
| 6 | BBC Virtus LifeSci Biotech Clinical Trials ETF | $46.4M | 0.65% | 1.54% | -5.0% | +11.2% | +36.6% | +37.8% | +0.2% | |
| 7 | IBBQ Invesco Nasdaq Biotechnology ETF | $96.4M | 0.19% | 1.1% | +1.1% | +25.7% | +36.3% | +26.1% | — | |
| 8 | LFSC F/M Emerald Life Sciences Innovation ETF | $126.3M | 0.54% | — | -3.0% | +17.8% | +35.8% | — | — | |
| 9 | CANC Tema Oncology ETF | $176.1M | 0.75% | 0.05% | +0.5% | +20.3% | +35.4% | +26.7% | — | |
| 10 | IBB iShares Biotechnology ETF | $9.09B | 0.44% | 0.16% | +1.2% | +25.8% | +35.3% | +23.9% | +6.4% |
Funds with less than $25 million in net assets and the 4 leveraged or inverse funds are left out of the ranking. Returns are total returns with distributions reinvested (3 and 5 years annualized), as of Oct 27, 2026.
How the top 5 compare
Growth of each fund’s value from the start of the range, distributions reinvested. The dashed gray line is the S&P 500 (SPY).
All 18 Biotechnology ETFs
Largest first. Click a heading to sort.
| Fund | Issuer | Net assets | Cost | Yield | YTD | 1 yr | 5 yr |
|---|---|---|---|---|---|---|---|
| XBI SPDR S&P Biotech ETF | SPDR (State Street) | $10.73B | 0.35% | 0.36% | +27.1% | +39.3% | +5.0% |
| IBB iShares Biotechnology ETF | iShares | $9.09B | 0.44% | 0.16% | +25.8% | +35.3% | +6.4% |
| FBT First Trust NYSE Arca Biotechnology Index Fund | First Trust | $2.81B | 0.55% | 0% | +32.5% | +43.6% | +11.4% |
| LABU Direxion Daily S&P Biotech Bull 3x Shares Leveraged | Direxion | $494.4M | 0.96% | 0.38% | +52.0% | +91.2% | -24.4% |
| BBH VanEck Biotech ETF | VanEck | $395.6M | 0.35% | 0.38% | +32.0% | +41.0% | +5.4% |
| PBE Invesco Biotechnology & Genome ETF | Invesco | $281.9M | 0.59% | 1.32% | +24.0% | +38.6% | +6.8% |
| CANC Tema Oncology ETF | Tema Global Ltd. | $176.1M | 0.75% | 0.05% | +20.3% | +35.4% | — |
| SBIO ALPS Medical Breakthroughs ETF | ALPS | $161.8M | 0.5% | 0% | +8.3% | +25.0% | +5.0% |
| LFSC F/M Emerald Life Sciences Innovation ETF | 1251 Capital Group Inc. | $126.3M | 0.54% | — | +17.8% | +35.8% | — |
| BIB ProShares Ultra Nasdaq Biotechnology Leveraged | ProShares | $101.4M | 0.95% | 0.19% | +44.6% | +67.2% | +6.1% |
| BBP Virtus LifeSci Biotech Products ETF | Virtus Investment Partners | $98.5M | 0.34% | 0% | +31.2% | +40.3% | +15.6% |
| IBBQ Invesco Nasdaq Biotechnology ETF | Invesco | $96.4M | 0.19% | 1.1% | +25.7% | +36.3% | — |
| LABD Direxion Daily S&P Biotech Bear 3x Shares Inverse | Direxion | $54.2M | 1.07% | 6.58% | -65.3% | -74.4% | -49.5% |
| FMED Fidelity Disruptive Medicine ETF | Fidelity | $51.5M | 0.5% | 0% | +20.2% | +21.5% | — |
| BBC Virtus LifeSci Biotech Clinical Trials ETF | Virtus Investment Partners | $46.4M | 0.65% | 1.54% | +11.2% | +36.6% | +0.2% |
| CNCR Range Cancer Therapeutics ETF | Exchange Traded Concepts | $8.9M | 0.79% | 0% | 0.0% | 0.0% | -19.4% |
| WDNA WisdomTree BioRevolution Fund | WisdomTree | $2.7M | 0.45% | 3.21% | +42.0% | +44.5% | +0.4% |
| BIS ProShares UltraShort Nasdaq Biotechnology Inverse | ProShares | $1.9M | 0.95% | 4.11% | -40.7% | -49.8% | -21.1% |
Picking funds is the easy part
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