F/M Emerald Life Sciences Innovation ETF

LFSC1251 Capital Group Inc.Equity
Expense ratio0.54%
Net assets$126.3M
Holdings38
Yield (TTM)—
1 week+1.7%
1 month-3.0%
3 months-4.8%
6 months+14.5%
YTD+17.8%
1 year+35.8%

Total returns with distributions reinvested; * a year. Prices as of Oct 27, 2026 · filings through Aug 31, 2026 · page updated Nov 3, 2026

At a glance

LFSC charges 0.54% a year, above the 0.52% average of the 5 funds most like it (the 4th cheapest of 6). It has $126.3M in assets, the 6th largest of that group. Over the past year it returned +35.8% with distributions reinvested (S&P 500: +11.5%), 3rd of those 6 funds. Its ten largest positions make up 54.0% of the fund, out of 38 in all.

The short version

F/M Emerald Life Sciences Innovation ETF (LFSC) is an actively managed fund. Its sub-adviser, Emerald Mutual Fund Advisers Trust, picks biotech, drug, diagnostics and medical device stocks that it sees as innovative. The fund is concentrated, with 38 holdings and about 54% in its top 10 as of August 31, 2026. Its expense ratio is 0.54% after a fee waiver, close to the 0.52% average of similar funds.

Price history

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LFSC +35.8% over the year to Oct 27, 2026, total return with distributions reinvested.

Prices through Oct 27, 2026. Total return: the price with distributions reinvested.

How it has behaved

Volatility (1 year)27.4%annualized; the S&P 500 is usually 15–20%
Worst drop (1 year)-17.6%all history: -29.7%
Beta vs S&P 5001.20moves about with the market
Sharpe ratio (1 year)1.16return above cash per unit of risk
Since launch+31.8%a year over 2 years
52-week range$31.32 – $48.44
Last price $43.12 on Oct 27, 2026, 11.0% below the 52-week high · above its 200-day average ($40.44).
YTD1 yr3 yr5 yr10 yrSince start
LFSC price data to Oct 27, 2026+17.8%+35.8%———+31.8%
Multi-year figures are annualized total returns with distributions reinvested. "Official" figures are the SEC-standard returns from the fund's prospectus; the price-data row is computed from daily prices.
  • Over the year to Oct 27, 2026, LFSC returned +35.8%, 3rd of 6 among similar funds.
  • Its worst full calendar year was 2025 (+56.5%); its best was 2025 (+56.5%).
  • The deepest fall in its price history was 29.7% (Nov 11, 2024 to Apr 8, 2025), recovered by Aug 22, 2025.
57%202518%2026*
57%202518%2026*
Calendar-year total returns from price data, distributions reinvested. * 2026 is year to date.
Show as a table
YearPrice data
2026 (to date)+17.8%
2025+56.5%
2008 financial crisis
stocks fell Oct 9, 2007 – Mar 9, 2009
Before this security existed
2020 COVID crash
stocks fell Feb 19, 2020 – Mar 23, 2020
Before this security existed
2022 bear market
stocks fell Jan 3, 2022 – Oct 12, 2022
Before this security existed

What's inside

As of Aug 31, 2026, the fund held 38 securities; the ten largest made up 53.98% of assets.

HoldingWeight
Travere Therapeutics Inc8.71%
Corcept Therapeutics Inc6.72%
Spyre Therapeutics Inc6.70%
LivaNova PLC6.61%
Cogent Biosciences Inc6.48%
Mirum Pharmaceuticals Inc4.32%
Billiontoone Inc3.86%
Guardant Health Inc3.81%
Cytokinetics Inc3.50%
United Therapeutics Corp3.27%
Axsome Therapeutics Inc3.05%
Nektar Therapeutics2.97%
TransMedics Group Inc2.91%
Savara Inc2.87%
VeraDermics Inc2.87%

By country

United States 93.43%United Kingdom 6.61%

By asset type

Stocks 100.04%
Source: N-PORT holdings report as of Aug 31, 2026. Cash, money-market funds and derivatives are shown separately from the securities list.

What changed recently

  • Over the three months to Aug 31, 2026, investors added a net $3.9M (creations minus redemptions, per the N-PORT report).
  • Monthly total returns reported for that quarter: +14.69%, +0.99%, +0.38%.

How it works

LFSC does not track an index. Its sub-adviser, Emerald Mutual Fund Advisers Trust, picks the stocks under the supervision of the fund's adviser. It uses what it calls a proprietary 10-step research process, and the goal is long-term growth. The managers look for life science companies that are focused on, or expected to gain from, one of three things. The first is technological advancement, meaning turning new science into products. The second is market disruption, meaning challenging established business models. The third is artificial intelligence. Target fields include biotechnology, pharmaceuticals, diagnostics, medical devices, health care services, health technology and synthetic biology.

In normal markets, at least 80% of net assets go into innovative life science companies. These come from specific health care subsectors of the FTSE Russell Industry Classification Benchmark, such as biotechnology, pharmaceuticals and medical equipment. The prospectus does not set a weighting formula or a rebalancing schedule, so the managers decide how much to put in each stock. Portfolio turnover was 19%, which points to fairly modest trading.

The fund holds ordinary stocks. As of August 31, 2026, it owned 38 companies and used no derivatives. About 93% was in US companies and about 7% in the UK, through LivaNova. The fund may also buy foreign shares, depositary receipts (US-traded certificates that stand for foreign stocks) and newly public companies, all of which can add volatility.

What it really costs

  • LFSC charges 0.54% a year, versus an average of 0.52% for the similar funds below (4th of 6, cheapest first).
  • Of that, 0.79% is the management fee; the rest covers other fund expenses.
  • The fee includes a 0.25% waiver from the adviser, which may end.
  • Using the prospectus's standard example, $10,000 invested would cost about $55 in the first year and $955 over 10 years (assuming a 5% annual return).
Cost of $10,000 (SEC example)1 yr3 yrs5 yrs10 yrs
LFSC$55$227$414$955
SEC standard example: $10,000 invested, 5% annual return, shares sold at the end of each period.

In a retirement portfolio

RoleSatellite (higher risk)

A concentrated, actively managed group of 38 life science stocks with a beta of 1.2 and no income fits better as a small add-on than as a foundation.

LFSC could add focused exposure to biotech and medical innovation, but it has a short history and big price swings. It launched on October 30, 2024, so it has no record through the 2008, 2020 or 2022 downturns. Its deepest drop was 29.7%, from November 11, 2024 to April 8, 2025. It got back to its old peak on August 22, 2025, about 4.5 months after the low. Volatility was 27.4% over the year to October 27, 2026. Its only full calendar year, 2025, returned 56.5%, so its "worst year" says little about how it might hold up in a real bear market. Someone who has to sell in a bad year could end up selling after a sharp fall. The fund costs 0.54% a year and has paid no distributions, so it provides no income. Past results don't predict the future, and a plan should look at the whole portfolio, not one fund.

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Who it may suit — and who should look elsewhere

May suit

  • Investors who want a manager's picks in biotech, drugmakers and medical devices rather than an index, and accept a concentrated 38-stock portfolio.
  • Those adding a small growth-focused satellite next to a broad core fund, who don't need any income from this position.
  • Holders who can sit through drops like its 29.7% fall from November 2024 to April 2025 without needing to sell.

Look elsewhere if

  • Retirees looking for income: the fund has paid no distributions.
  • Cost-focused investors: SPDR S&P Biotech ETF (XBI) charges 0.35% against LFSC's 0.54%, though the two share only 13% of holdings.
  • Anyone who wants a long track record: LFSC launched in October 2024 and has never been through a major bear market.

Close alternatives

Matched by closest holdings overlap from the latest N-PORT reports (no similar fund shares 20% or more of its holdings).

FundOverlapCostNet assets1 yr3 yr
LFSC this fund—0.54%$126.3M+35.8%—
XBI SPDR S&P Biotech ETF13%0.35%$10.73B+39.3%+34.4%
SBIO ALPS Medical Breakthroughs ETF13%0.5%$240.0M+25.0%+34.8%
FBT First Trust NYSE Arca Biotechnology Index F…12%0.56%$2.81B+43.6%+27.7%
IBB iShares Biotechnology ETF7%0.45%$9.09B+35.3%+23.9%
CANC Tema Oncology ETF7%0.75%$211.1M+35.4%+26.7%
Net assets from each fund's latest N-PORT or annual report where available. Returns through Oct 27, 2026.

Questions investors ask

Does LFSC pay a dividend?

No. The fund has recorded no distributions, so it has no yield to report. Its goal is long-term capital appreciation, which means growth in the share price, not income. Many of its holdings are drug developers and medical technology companies, a group that tends to reinvest cash rather than pay it out. Anyone who needs regular cash from this fund would have to sell shares, which can mean selling at a low price after a drop.

What is the expense ratio of LFSC?

LFSC's expense ratio is 0.54%, according to its prospectus filed December 30, 2025. That is a 0.79% management fee minus a 0.25% fee waiver. In the SEC's standard example, $10,000 earning 5% a year would cost about $55 in the first year, $227 over three years, $414 over five years and $955 over ten. Similar funds average 0.52%, and LFSC ranks 4th lowest in cost out of 6.

What's the difference between LFSC and XBI?

The main difference is how the stocks are chosen. LFSC is actively managed, with 38 hand-picked life science stocks as of August 31, 2026. SPDR S&P Biotech ETF (XBI) costs less, at 0.35% against 0.54%. It is also much bigger, with about $10.7 billion in net assets as of June 30, 2026, against about $126 million for LFSC as of August 31, 2026. The two share only 13% of holdings. Over the year to October 27, 2026, XBI returned 39.3% and LFSC returned 35.8%.

Is LFSC good for a retirement portfolio?

It may suit a small satellite position, but it is not built to be a core holding. Over the year to October 27, 2026, its beta was 1.2, meaning it moved more than the market, and its volatility was 27.4%. It fell 29.7% from November 2024 to April 2025 before recovering in August 2025. It pays no income. Because it launched in October 2024, it has no record in a major bear market.

What are LFSC's top holdings?

As of August 31, 2026, the largest positions were Travere Therapeutics (8.7%), Corcept Therapeutics (6.7%), Spyre Therapeutics (6.7%), LivaNova (6.6%) and Cogent Biosciences (6.5%). The top 10 made up about 54% of the fund. That means bad news at one or two companies, such as a failed drug trial, could noticeably move the share price. About 93% of assets were in US companies, and the rest was in UK-based LivaNova.

Sources

  • 485BPOS prospectus (risk/return XBRL), filed Dec 30, 2025 — SEC EDGAR
  • N-PORT holdings report, filed Oct 30, 2026 — SEC EDGAR
  • Prices: daily prices and distributions through Oct 27, 2026

For education only, not investment advice. Past performance does not predict future results.