The 5 top performers
| # | Fund | 30 days | Net assets | Cost | Yield | 1 mo | YTD | 1 yr | 3 yr | 5 yr |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | FTXH First Trust Nasdaq Pharmaceuticals ETF | $36.2M | 0.6% | 0.67% | +3.5% | +31.5% | +46.9% | +23.4% | +12.6% | |
| 2 | IHE iShares U.S. Pharmaceuticals ETF | $1.14B | 0.37% | 1.38% | +0.8% | +22.9% | +39.8% | +25.0% | +12.8% | |
| 3 | PJP Invesco Pharmaceuticals ETF | $472.1M | 0.58% | 0.89% | -0.4% | +21.8% | +34.0% | +24.3% | +11.3% | |
| 4 | XPH SPDR S&P Pharmaceuticals ETF | $428.4M | 0.35% | 0.42% | -3.2% | +14.5% | +30.8% | +23.1% | +7.6% | |
| 5 | PPH VanEck Pharmaceutical ETF | $879.5M | 0.36% | 1.86% | +3.3% | +13.0% | +26.4% | +17.9% | +11.5% |
Funds with less than $25 million in net assets and the 1 leveraged or inverse funds are left out of the ranking. Returns are total returns with distributions reinvested (3 and 5 years annualized), as of Oct 27, 2026.
How the top 5 compare
Growth of each fund’s value from the start of the range, distributions reinvested. The dashed gray line is the S&P 500 (SPY).
All 6 Pharmaceutical ETFs
Largest first. Click a heading to sort.
| Fund | Issuer | Net assets | Cost | Yield | YTD | 1 yr | 5 yr |
|---|---|---|---|---|---|---|---|
| IHE iShares U.S. Pharmaceuticals ETF | iShares | $1.14B | 0.37% | 1.38% | +22.9% | +39.8% | +12.8% |
| PPH VanEck Pharmaceutical ETF | VanEck | $879.5M | 0.36% | 1.86% | +13.0% | +26.4% | +11.5% |
| PJP Invesco Pharmaceuticals ETF | Invesco | $472.1M | 0.58% | 0.89% | +21.8% | +34.0% | +11.3% |
| XPH SPDR S&P Pharmaceuticals ETF | SPDR (State Street) | $428.4M | 0.35% | 0.42% | +14.5% | +30.8% | +7.6% |
| FTXH First Trust Nasdaq Pharmaceuticals ETF | First Trust | $36.2M | 0.6% | 0.67% | +31.5% | +46.9% | +12.6% |
| PILL Direxion Daily Pharmaceutical & Medical Bull 3X S… Leveraged | Direxion | $20.7M | 0.98% | 0.41% | +20.0% | +73.8% | -2.2% |
Picking funds is the easy part
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