The 10 top performers
| # | Fund | 30 days | Net assets | Cost | Yield | 1 mo | YTD | 1 yr | 3 yr | 5 yr |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | ARKG ARK Genomic Revolution ETF | $1.56B | 0.75% | 0% | -3.2% | +78.3% | +65.8% | +32.4% | -6.8% | |
| 2 | FTXH First Trust Nasdaq Pharmaceuticals ETF | $36.2M | 0.6% | 0.67% | +3.5% | +31.5% | +46.9% | +23.4% | +12.6% | |
| 3 | BBH VanEck Biotech ETF | $395.6M | 0.35% | 0.38% | +1.8% | +32.0% | +41.0% | +20.9% | +5.4% | |
| 4 | IHE iShares U.S. Pharmaceuticals ETF | $1.14B | 0.37% | 1.38% | +0.8% | +22.9% | +39.8% | +25.0% | +12.8% | |
| 5 | XBI SPDR S&P Biotech ETF | $10.73B | 0.35% | 0.36% | -0.1% | +27.1% | +39.3% | +34.4% | +5.0% | |
| 6 | IBB iShares Biotechnology ETF | $9.09B | 0.44% | 0.16% | +1.2% | +25.8% | +35.3% | +23.9% | +6.4% | |
| 7 | XPH SPDR S&P Pharmaceuticals ETF | $428.4M | 0.35% | 0.42% | -3.2% | +14.5% | +30.8% | +23.1% | +7.6% | |
| 8 | XLV Health Care Select Sector SPDR Fund | $40.60B | 0.08% | 1.38% | +9.8% | +20.9% | +30.2% | +16.2% | +8.4% | |
| 9 | VHT Vanguard Health Care ETF | $22.04B† | 0.09% | 1.35% | +8.3% | +20.1% | +28.9% | +16.9% | +7.3% | |
| 10 | PSCH Invesco S&P SmallCap Health Care ETF | $183.9M | 0.29% | 0% | +3.7% | +24.3% | +28.0% | +16.4% | -1.1% |
Funds with less than $25 million in net assets and the 4 leveraged or inverse funds are left out of the ranking. Returns are total returns with distributions reinvested (3 and 5 years annualized), as of Oct 27, 2026.
How the top 5 compare
Growth of each fund’s value from the start of the range, distributions reinvested. The dashed gray line is the S&P 500 (SPY).
All 33 Health Care ETFs
Largest first. Click a heading to sort.
| Fund | Issuer | Net assets | Cost | Yield | YTD | 1 yr | 5 yr |
|---|---|---|---|---|---|---|---|
| XLV Health Care Select Sector SPDR Fund | SPDR (State Street) | $40.60B | 0.08% | 1.38% | +20.9% | +30.2% | +8.4% |
| VHT Vanguard Health Care ETF | Vanguard | $22.04B† | 0.09% | 1.35% | +20.1% | +28.9% | +7.3% |
| XBI SPDR S&P Biotech ETF | SPDR (State Street) | $10.73B | 0.35% | 0.36% | +27.1% | +39.3% | +5.0% |
| IBB iShares Biotechnology ETF | iShares | $9.09B | 0.44% | 0.16% | +25.8% | +35.3% | +6.4% |
| IXJ iShares Global Healthcare ETF | iShares | $3.84B | 0.38% | 1.33% | +13.2% | +19.5% | +6.4% |
| IYH iShares U.S. Healthcare ETF | iShares | $3.56B | 0.37% | 1.05% | +16.9% | +23.8% | +7.1% |
| FHLC Fidelity MSCI Health Care Index ETF | Fidelity | $3.29B | 0.08% | 1.17% | +17.0% | +23.8% | +7.2% |
| IHI iShares U.S. Medical Devices ETF | iShares | $3.02B | 0.37% | 0.48% | -11.9% | -12.2% | -2.9% |
| ARKG ARK Genomic Revolution ETF | ARK Invest | $1.56B | 0.75% | 0% | +78.3% | +65.8% | -6.8% |
| IHF iShares U.S. Healthcare Providers ETF | iShares | $1.18B | 0.37% | 0.91% | +24.5% | +16.5% | +2.4% |
| IHE iShares U.S. Pharmaceuticals ETF | iShares | $1.14B | 0.37% | 1.38% | +22.9% | +39.8% | +12.8% |
| FXH First Trust Health Care AlphaDEX Fund | First Trust | $1.05B | 0.61% | 0.55% | +19.2% | +19.7% | +3.1% |
| PPH VanEck Pharmaceutical ETF | VanEck | $879.5M | 0.36% | 1.86% | +13.0% | +26.4% | +11.5% |
| SIXH ETC 6 Meridian Hedged Equity Index Option ETF | Exchange Traded Concepts | $603.2M | 0.69% | 1.73% | +16.0% | +19.6% | +10.4% |
| LABU Direxion Daily S&P Biotech Bull 3x Shares Leveraged | Direxion | $494.4M | 0.96% | 0.38% | +52.0% | +91.2% | -24.4% |
| XPH SPDR S&P Pharmaceuticals ETF | SPDR (State Street) | $428.4M | 0.35% | 0.42% | +14.5% | +30.8% | +7.6% |
| BBH VanEck Biotech ETF | VanEck | $395.6M | 0.35% | 0.38% | +32.0% | +41.0% | +5.4% |
| PSCH Invesco S&P SmallCap Health Care ETF | Invesco | $183.9M | 0.29% | 0% | +24.3% | +28.0% | -1.1% |
| CURE Direxion Daily Healthcare Bull 3x Shares Leveraged | Direxion | $171.7M | 0.94% | 0.83% | +38.6% | +61.4% | +6.7% |
| SBIO ALPS Medical Breakthroughs ETF | ALPS | $161.8M | 0.5% | 0% | +8.3% | +25.0% | +5.0% |
| XHE SPDR S&P Health Care Equipment ETF | SPDR (State Street) | $151.4M | 0.35% | 0.02% | +5.7% | +14.1% | -5.6% |
| KURE KraneShares MSCI All China Health Care Index ETF | KraneShares | $71.2M | 0.65% | 4.02% | +3.7% | -5.7% | -9.4% |
| LABD Direxion Daily S&P Biotech Bear 3x Shares Inverse | Direxion | $54.2M | 1.07% | 6.58% | -65.3% | -74.4% | -49.5% |
| FMED Fidelity Disruptive Medicine ETF | Fidelity | $51.5M | 0.5% | 0% | +20.2% | +21.5% | — |
| MEDI Harbor Health Care ETF | Harbor | $41.2M | 0.8% | 0.47% | +7.8% | +12.6% | — |
| FTXH First Trust Nasdaq Pharmaceuticals ETF | First Trust | $36.2M | 0.6% | 0.67% | +31.5% | +46.9% | +12.6% |
| HEAL Global X HealthTech ETF | Global X | $25.0M | 0.5% | 0.23% | +6.2% | -6.4% | — |
| GDOC Future Health Care Equity ETF | Goldman Sachs | $19.6M | 0.75% | 0.29% | +6.7% | +9.7% | — |
| MEDX Horizon Kinetics Medical ETF | Horizon Kinetics Holding Corp. | $19.1M | 0.85% | 1.11% | +11.1% | +19.1% | — |
| BMED iShares Health Innovation Active ETF | iShares | $11.2M | 0.55% | 0.22% | +17.9% | +24.8% | +4.0% |
| CNCR Range Cancer Therapeutics ETF | Exchange Traded Concepts | $8.9M | 0.79% | 0% | 0.0% | 0.0% | -19.4% |
| RXD ProShares UltraShort Health Care Inverse | ProShares | $2.9M | 0.95% | 2.74% | -26.2% | -34.6% | -12.0% |
| WDNA WisdomTree BioRevolution Fund | WisdomTree | $2.7M | 0.45% | 3.21% | +42.0% | +44.5% | +0.4% |
Picking funds is the easy part
ReadyAimRetire shows whether your whole plan works, with your accounts, Social Security, taxes and spending, year by year.